Abstract: In order to ensure the safe operation of ventilation air methane (VAM) thermal oxidation utilization project, the safety risks of low concentration gas transportation system, VAM mixing system and VAM thermal oxidation furnace were firstly analyzed. Aiming at these risks, a gas transportation safety guarantee system based on three different principles, namely, water seal fire release and explosion elimination, automatic explosion suppression and automatic explosion resistance was designed. At the same time, an emergency treatment system for excess concentration of mixed gas, and an integrated safety guarantee system for the operation of thermal oxidation furnace with anti-overtemperature, anti-overpressure and automatic explosion venting were designed. The safety design was carried out in the heating wellbore project by VAM thermal oxidation in a mine in Shanxi Province, and the rationality, reliability and stability of the design were verified by practical operation.