Abstract: To counter the asymmetric deformation and failure of the soft rock raodway in gently inclined coal seam in Zaoquan Mine, FLAC^3D numerical analysis method was used and the asymmetric deformation law of the surrounding rock of the soft rock roadway of the inclined seam was obtained, which was then verified with the field rock pressure monitoring result. A multi-medium combined support technology with anchor cable and bolting wire mesh and so on was applied to take together the broken rock body with the deep stable rock body and form a "compression arch" under the common action of the anchor cable and bolting wire mesh, which improved the development trend of the natural self-supprting arch formed over the roof along the coal seam bedding to the top corner of the roadway, fully exerted the whole mechanical effect of the anchor cable, bolting wire mesh and surrounding rock and effectively controlled the deformation and failure of the roadway surrounding rock, and good effect was achieved in the production practice.