Abstract: In order to make the mine ventilation system operate safely, efficiently and economically, the ventilation system parameters were obtained through field tests. 858 indexes were precipitated by literature precipitation according to relevant national standards. By adding, deleting and merging indexes, a preliminary index system consisting of 20 indexes was established. Through the correlation analysis of the index system, it was found that KMO> 0.7 and Bartlett spherical test value < 0.001, the index information had overlapping phenomenon. The preliminary index system was briefed by factor analysis method, the index system of mine ventilation system composed of 16 indexes was established from 5 aspects. It included two new indexes, namely the standard degree of mine air resistance and the stability coefficient of fan operation. The formulas for calculating the reasonable degree of resistance distribution and the reasonable degree of resistance distribution in the three regions of the ventilation system were given quantitatively for the first time.