Abstract: In order to ensure the stability and safety of the roadway under the multi-roadway layout in 81505 fully mechanized working face of Shendong Baode Coal Mine, a numerical test model was established by using FLAC^3D numerical simulation software. The stress distribution, deformation and plastic zone distribution of surrounding rock when the width of gob-side pillar is 15.0 m, 20.0 m, 25.0 m, 30.0 m and 35.0 m under the single roadway layout and the width of pillars between roadways is 7.5 m, 10.0 m, 12.5 m, 15.0 m and 17.5 m under the multi-lane layout were studied and analyzed, the reasonable sizes of gob-side pillars and pillars between roadways were obtained by comparison. The results show that when the width of the gob-side pillar is 25.0 m and the width of the pillar between roadways is 12.5 m, the inner stress level of the coal pillar is low, the coal pillar is stable and the roadway deformation is small. A multi-mode combined support scheme of bolt, mesh and cable based on the principle of asymmetric support was proposed, and the scheme was suitable for the stoping roadway in 81505 fully mechanized working face of Baode Coal Mine. The engineering application results show that the deformation of surrounding rock is controllable and the coal pillar is stable, it means that the retention width and supporting parameters of the coal pillar are reasonable.