Abstract: In order to study the influence of roadway crossing on local ventilation resistance of mine ventilation system, the ventilation of the roadway in Chengjiao Coal Mine was taken as the engineering background. Numerical simulation and field measurement were adopted to determine the effect of confluence, shunt, obtuse-angle, and acute-angle on the resistance loss of crossing roadway. The results show that the resistance loss of confluence is smaller than that of shunt, the resistance loss of acute-angle confluence is smaller than that of obtuse-angle. Therefore, in the design of roadway, shunt and obtuse confluence should be minimized to avoid airflow sharp rotation when the roadway crosses, so as to reduce local ventilation resistance.