Abstract: To counter the serious dust hazard in the fully mechanized coal face in Qipanjing Coal Mine, coal seam water infusion test was conducted inⅠ020902 working face in this mine, and experimental analysis was made on the water infusion suitability of the coal seam from the original water content, porosity, natural water absorption and consistent coefficient of coal. In order to achieve better dust removal effect, the drilling parameters, water infusion parameters and hole-sealing technology were all optimized and compared. The field test results showed that under the conditions of the injection pressure of 7 MPa, the hole spacing of 15 m, the single hole infusion volume of 370 m³, the infusion flow of 2.1 m³/h, the single hole infusion time of 8 d, simultaneous infusion by 3 holes, the hole being sealed by cement-water glass and the sealing depth of 8 m, the dust removal effect by coal seam water infusion was better, the removal efficiecy of the total dust in the working face can reach 86.38%, and the removal efficiency of respirable dust can reach 75.94%.