Abstract: In view of the problem that multiple factors in fluencing the spontaneous combustion of coal mines, and the process of it is complex and varied, a method of safety evaluation of spontaneous combustion in coal mines is proposed by combining entropy method and mutation theory.The evaluation index system with 4 grade of spontaneous combustion safety in coal mines was established, including 3 secondary indicators, 7 tertiary indicators and 19 cet-4 indicators, the secondary indicators are environment and management, human factors and physical factors. According to the actual situation of Songhe Coal Mine in Guizhou province, the spontaneous combustion was evaluated by the method, and the total mutation membership value of the coal mine was 0.612.The safety of this coal mine is medium, the air leakage in goaf was serious in environment and management, and it has poor heat dissipation conditions and many left coal, which were the main reason for the low safety of coal mine. It is in line with the basic safety condition of the coal mine and verifies the practicability of the evaluation method.