Abstract: In this paper, aiming at the actual problem of high gas concentration during the operation of 3434 heading face of Liangbaosi Coal Mine, with the purpose of gas prevention and control, based on the self-developed test system of true triaxial gas-solid coupling coal seepage flow, the experiment of unloading confining pressure and axial compression was carried out based on the stress distribution of coal surrounding the heading face, the evolution of permeability in each stress zone was studied, the gas storage was analyzed.The experimental results showed that it is suitable for methane emission when the permeability of pressure relief zone increases, and the gas is difficult to escape when and the permeability is decreased in the stress zone.The gas treatment scheme was designed according to the experimental results and the characteristics of stress zone, and the engineering practice was carried out.Practice showed that the range of gas concentration was from 0.53% to 0.76%, and after the gas of coal seam extracted with advanced drilling, the gas concentration decreased to lower than 0.35%, it proved the correctness of the stress-seepage relationship research.