Abstract: In view of the current situation that most coal mines have weak local airflow management, in order to ensure that the ventilation system can stably and reliably deliver enough fresh airflow to the downhole wind locations to dilute the harmful gases in the underground and adjust the mine temperature. Based on three-dimensional simulation technology, the three-dimensional simulation system of mine ventilation network was developed. This paper introduces the technical framework of the system, and expounds design idea of the system, architecture and functions of the software system, etc. The application example shows that the three-dimensional simulation system of mine ventilation network can realize real-time simulation of mine air flow and dynamic display of roadway ventilation, once the abnormal situation of ventilation is found, it can provide real-time alarm, which can provide effective technical means for the safety management of mine ventilation.