Abstract: According to the operation characteristics of the gas oxidation device, combined the current situation of gas drainage and the requirements of mine ventilation in China, this paper analyzed the key safety hazards in the operation of coal mine gas oxidation device. It also put forward the technical requirements for security operation in key procedures such as mixing of drainage gas with ventilation air methane, delivering of drainage gas. In this paper, the design of safeguard system of the ventilation air methane and the low concentration gas mixing device, the mixing monitoring system and the gas drainage station was introduced.The test results during the period of Gaohe gas oxidation and power generation project showed that the reasonable designing mix device with corresponding monitoring system and transportation security system of low concentration gas can ensure the safe and effective operation of gas oxidation device, and cause no harm to the coal mine gas drainage system and the safety production.