Abstract: Four shafts on the ground were closed after the coal spontaneous fire of Shajihai Coal B6101 working face, in order to unseal the shaft as soon as possible, the scheme of drilling down and pouring the Tiangu sealing material from the ground to isolate B6101 working face sealed fire area was established.The CO and O₂ gas concentration changes, as well as the internal and external pressure difference were analyzed before and after the isolation of fire zone in the borehole and return air shaft. The result showed that the fire area isolation was good.Effective isolation of the B6101 workface fire zone contributed to ensuring safety of mine equipment and unsealing mine timely.