Abstract: The coal industry is a high-incidence industry of occupational diseases and involves many occupational hazards, in order to evaluate the hazards of coal mine comprehensively, based on the theory of uncertainty measurement, a total of 11 occupational hazard discrimination indexes including dust mass concentration, harmful gas, gas concentration (methane volume fraction), noise, vibration, temperature, humidity, wind speed, effective air volume rate, working space and labor intensity were selected to establish an occupational hazard evaluation index system, the information entropy was used to determine the weight of each index, and the level was judged according to the confidence recognition criteria, and the evaluation result was finally obtained. Based on the uncertainty measurement evaluation model of occupational hazard in coal mine, Visual Basic programming technology was applied to realize the programmatic evaluation of the evaluation model. The evaluation model was applied to the comprehensive evaluation of occupational hazards in 6 kinds of underground work in Tongxin Coal Mine, and the evaluation results were consistent with the actual situation, indicating that the evaluation model and its application program can objectively and accurately evaluate the occupational hazards in coal mine.