Abstract: In order to effectively control the explosion risk of the closed container connected with the pipeline and reduce the input cost of manufacturing and maintenance, the influence of flexible pipeline on the explosion pressure of the closed container connected with the pipeline was studied through numerical calculation and actual explosion test. Taking the flameproof enclosure as the research object, the mathematical model of numerical calculation was selected, the numerical model and boundary conditions were determined, and the difference of explosion pressure inside the enclosure was compared when the valve was closed and opened. When flexible pipes of different diameters were connected, the gas flow and pressure distribution at the pipe interface during explosion were analyzed. The flexible pipe connection flameproof enclosure was tested in the explosion tank, and the test and numerical calculation results were compared and analyzed. The research results show that the flexible pipeline has the effect of explosion relief, and the larger the diameter of the pipeline, the smaller the internal explosion pressure.