Abstract: In view of the complex working environment, such as many hidden risks and inadequate investigation and management of one-ventilation and three-prevention in coal mines. By reviewing relevant literature and safety regulations, consulting experts and other methods, the risk evaluation indicators for one-ventilation and three-prevention were selected. The evaluation indicators were optimized and the corresponding evaluation index system was established by combining the results of on-site surveys. The improved analytic hierarchy process and entropy weight method were used to calculate the subjective and objective weights. Based on game theory, the subjective and objective combination weights are calculated. The TOPSIS comprehensive evaluation method was introduced to construct the combination weighting-TOPSIS evaluation model. Finally, according to the application on the risk assessment of one-ventilation and three-prevention in five coal mines in Binchang Mining Company of Xianyang City, Shaanxi Province, the results showed that the constructed combination weighting-TOPSIS evaluation model was basically consistent with the actual situation.