Abstract: Based on the engineering geological background of the affected area of the inner fold wing in the seventh mining area of Baojishan Coal Mine, the mechanism of induced rock burst by inclination change of mining coal seam was studied through on-site statistic, theoretical calculation and numerical simulation. A collaborative control solution for preventing and controlling rock burst was proposed, and on-site industrial experiments were conducted. The results show that with the increase of coal seam inclination, the concentrated static stress in the coal pillar side gradually increase, while the concentrated static stress in the solid coal side gradually decrease. Under the condition of smaller inclination, the thick and hard key layer is more likely to break at the boundary on both sides of the goaf, which will induce the central area of its suspended section to break instantaneously and form a far-field stress disturbance with large disturbance intensity. Key block B is prone to rotate instability under the conditions of small coal seam inclination and large burial depth, leading to form a near-field stress disturbance with small disturbance intensity. The proposed method has a significant effect on the prevention and control of rock burst.