Abstract: Based on the slope engineering of Niukutou open pit metal mine in Qinghai Province, firstly, the slope was divided into 5 geological areas according to geological factors and engineering factors. Then the geological survey data and laboratory test data were statistically classified, and the Chinese Slope Mass Rating (CSMR) method was used to grade and evaluate the slope. Representative sections were selected for two-dimensional numerical calculation and analysis, and GEO-SLOPE was used for preliminary calculation of slope stability, and MSARMA method was used to comprehensively consider the drainage capacity and seismic load of the slope for limit equilibrium analysis. Finally, the appropriate slope angle was optimized according to the analysis and calculation results and actual working conditions.