Abstract: In order to guide the mine pressure prevention and control of island face in large dip angle coal seam, taking 203 working face in the Wangjiashan Coal Mine as the engineering background, by using the numerical simulation and field practice, the evolution law of mining stress and rock burst risk of such island working face were revealed. The results show that under the coupling influence of the northern goaf, the small kiln damage area and the eastern goaf, the mining stress concentration degree at the return airway side is higher than that at the transportation gateway side of 203 working face; there are double shear zones in the top coal and bottom coal around the 203 working face, which leads to that the top coal on the side of roof is easy to be broken and released under the action of gravity, while the stress concentration degree of roof side of bottom coal is further intensified. Based on the results of mining stress concentration coefficient K partition and field drilling cuttings monitoring, the return airway of 203 working face is the key area of mine pressure prevention. The grading measures combined with large-diameter pressure-relief drilling and pressure-relief blasting are proposed and implemented on site, which achieves a remarkable effect.