Abstract: In view of the problem that the deformation of surrounding rock during the service period after the formation of deep roadway with large section is relatively serious, the deformation of the roof and bottom plate and the two sides are relatively large, based on Mohr-Coulomb criterion and mechanical balance principle, the grouting modification mechanism and the grouting mechanical model of surrounding rock are analyzed; FLAC^3D numerical simulation is used to compare and analyze the layered tunneling, top to bottom tunneling at one time, grouting reinforcement and non-grouting reinforcement, as well as the evolution law of surrounding rock plastic zone, stress field, and surrounding rock displacement under this four cross support methods.The results show that after grouting reinforcement, the damage range of the plastic zone and the displacement of surrounding rock are significantly reduced, which effectively controls the deformation of surrounding rock of the roadway. The rock pressure control scheme of "layered tunneling + hysteretic high pressure grouting + strong anchor cable support" is qualitatively analyzed and determined. The practical application results show that this method can effectively control the deformation of roadway surrounding rock, which can provide a reference for the design and application of grouting reinforcement for surrounding rock of deep roadway with large section.